Skip Navigation

Household Products Database banner

Quick search

Advanced Search triangular bullet

Browse by category
Auto Products
Inside the Home
Personal Care
Home Maintenance
Arts & Crafts
Pet Care
Home Office
Commercial / Institutional

Browse A to Z
Products Names
Types of Products

Support pages
About the Database
Product Recalls
Contact Us
More Resources



Home Products Manufacturers Ingredients Health Effects
Product Information
Product Name: Ortho Isotox Insect Killer Formula IV
EPA Registration Code: 239-2595
Form: liquid
Product Category: Pesticides » caterpillars » Insecticide
Pesticides » beetles » Insecticide
Pesticides » ants » Insecticide
Pesticides » aphids » Insecticide
Customer Service: 888-295-0671
Date Entered: 2001-05-08
Related Items: Products with similar usage in this database
Manufacturer: Solaris Group, The
All Solaris products acquired by Ortho Group of Scotts Company
Address: P.O. Box 5008
City: San Ramon
State: CA
Zip Code: 94583
Toll Free Number: 888-295-0671
Date Info Verified: 2003-01-01
Related Items: Products by this manufacturer
The following information (Health Effects, Handling/Disposal, and Ingredients) is taken from the product label and/or the Material Safety Data Sheet (MSDS) prepared by the manufacturer. The National Library of Medicine does not test products nor does it evaluate information from the product label or the MSDS. (What is an MSDS?)
Health Effects
Enter text or highlight term...
Acute Health Effects: From MSDS
EYES: This substance is a severe eye irritant and could cause permanent damage to your eyes and blindness. The degree of the injury will depend on the amount of material that gets into the eye and the speed and thoroughness of the first aid treatment. Symptoms of overexposure may include discomfort, irritation and redness, and blurred vision.
SKIN: The undiluted product is considered a moderate skin irritant, therefore contact with the skin can cause prolonged (days) injury to the affected area. The degree of injury will depend on the amount of material that gets on the skin and the speed and thoroughness of the first aid treatment. Skin irritation may include redness, itching and swelling. This substance is considered slightly toxic to internal organs if absorbed through the skin.
INGESTION: This substance is slightly toxic to internal organs if swallowed. This product contains a petroleum distillate. Because of the low viscosity of the petroleum distillate, it can directly enter or be aspirated into the lungs either during swallowing or vomiting the substance. Once in the lungs, the substance is very difficult to remove and can cause severe injury to the lungs and death.
INHALATION: If inhaled, this substance is considered practically non-toxic to internal organs.
TARGET ORGANS: Acephate is an inhibitor of the cholinesterase enzyme, found in nervous tissue, red blood cells, and plasma.
Chronic Health Effects: From MSDS
SUB This product contains acephate, an organophosphate that is considered to be a cholinesterase inhibitor. Cholinesterase is an enzyme involved in the transmission of nerve impulses. Therefore, repeated daily exposure to the product can gradually lower the cholinesterase levels to a point that signs and symptoms of organophosphate poisoning may occur.
Results of the rat chronic acephate feeding study indicate that the no observed effect level (NOEL) was 5 parts per million (ppm) or (0.25 mg/kg/dy). Hexakis NOEL's for the rat chronic and 2-year dog studies are 2,000 and 16,000 ppm (100 and 400 mg/kg/dy), respectively.
The dog 2-year acephate feeding study NOEL for cholinesterase inhibition was 30 ppm (0.75 mg/kg/dy). The effect level for cholinesterase inhibition occurred at the high dose of 200 ppm (5 mg/kg/dy).
NEUROTOXICITY: Based on the results of the chicken neurotoxicity studies, acephate has not demonstrated potential to cause delayed neuropathy. Hexakis has not been associated with neuro-histopathological changes.
TERATOGENICITY: Neither acephate, or hexakis have been demonstrated to cause birth defects.
REPRODUCTIVE TOXIN: When male and female rats were fed acephate continuously for two generations through weaning of the third generation, animals in the mid and high-dose groups demonstrated compound-related effects on reproductive performance. The low-dose was considered the no-effect-level. There was no evidence of adverse reproductive effects in the hexakis rat 3 generation study.
MUTAGENICITY: Acephate has demonstrated weak mutagenic potential in microbes or cultured cells, while results of in vivo studies indicate that it does not cause mutation in whole animals. Hexakis is not considered to be a mutagen in either in vitro or in vivo studies.
Carcinogenicity: From MSDS
CARCINOGENICITY COMMENTS: EPA has classed acephate in category C as a possible human carcinogen based on the liver tumor findings in the mouse lifetime feeding study. Liver pathology was observed at dose levels of 250 and 1000 ppm (37.5 and 150 mg/kg/dy), while an increased incidence of liver cancer was noted in the high dose (150 mg/kg/dy) female mice only. Acephate has not demonstrated any evidence of carcinogenic potential in any other species.
Hexakis was not carcinogenic in either the rat or mouse lifetime feeding studies or the 2 year dog chronic study.
First Aid: From MSDS

EYES: Hold eye open and rinse slowly and gently with water for 15 to 20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eyes. Call a poison control center or doctor for treatment advice.
SKIN: If on skin or clothing, take off contaminated clothing. Rinse skin immediately with plenty of water for 15 to 20 minutes. Call a poison control center or doctor for treatment advice.
INGESTION: If swallowed, call a poison control center or doctor immediately for treatment advice. Have person sip glass of water if able to swallow. Do not induce vomiting unless told to by a poison control center or doctor. Never give anything by mouth to an unconscious person.
INHALATION: Move person to fresh air. If person is not breathing, call 911 or an ambulance, then give artificial respiration, preferably by mouth-to-mouth, if possible. Call a poison control center or doctor for further treatment advice.
NOTES TO PHYSICIAN: Ingestion of this product or subsequent vomiting can result in aspiration of light hydrocarbon liquid which can cause pneumonitis. This material contains a cholinesterase inhibitor. Measurement of blood cholinesterase activity may be useful in monitoring exposure. If signs of cholinesterase inhibition appear, atropine sulfate is antidotal. 2-PAM (PROTOPAM) is also antidotal and may be used in conjunction with atropine but should not be used alone.
Health Rating: 3
Flammability Rating: 3
Reactivity Rating: 0
HMIS Rating Scale: 0 = Minimal; 1 = Slight; 2 = Moderate; 3 = Serious; 4 = Severe; 
N = No information provided by manufacturer; * = Chronic Health Hazard
MSDS Date: 1997-02-14
Handling: From MSDS
GENERAL PROCEDURES: Store away from heat or open flame. Keep pesticide in original container. Do not put concentrate or dilute into food or drink containers. Avoid contamination of feed, foodstuffs. Store in a cool dry place, preferably in a locked storage area. Do not store diluted spray. Store above freezing. Handle concentrate in a ventilated area. Keep container closed.

ECOTOXICOLOGICAL INFORMATION: This material is toxic to fish and birds. Drift and runoff from treated areas may be hazardous to aquatic organisms in neighboring areas. Do not apply directly to water. Do not contaminate water by cleaning of equipment or disposal of wastes. Do not apply this product or allow it to drift to blooming crops or weeds if bees are visiting treatment area.
Disposal: From MSDS
If necessary to dispose of partially filled product container, securely wrap it in several layers of newspaper and discard in trash.
EMPTY CONTAINER: Do not reuse container. Rinse thoroughly before discarding in trash.
Ingredients from MSDS/Label
ChemicalCAS No / Unique IDPercent
Toximul 3406F000000-18-2
Inert ingredients (unspecified)999999-00-291.5
HHS.GOV Household Products Database Home Page National Institutes of Health National Library of Medicine Specialized Information Services National Library of Medicine